This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: The authors received no specific funding for this work.Ĭompeting interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: Simeon Pierre Choukem (one of the co-authors) is an Academic Editor for PLOS ONE journal. Received: DecemAccepted: Published: June 10, 2021Ĭopyright: © 2021 Fokoua-Maxime et al.
Spradley, University of Mississippi Medical Center, UNITED STATES Finally, sensitivity analyses will be performed to measure the impact of low-quality studies on the results of the meta-analysis, and power calculations will determine the probability that we will detect a true effect if it does exist.Ĭitation: Fokoua-Maxime CD, Lontchi-Yimagou E, Cheuffa-Karel TE, Tchato-Yann TL, Pierre-Choukem S (2021) Prevalence of asymptomatic or “silent” myocardial ischemia in diabetic patients: Protocol for a systematic review and meta-analysis. Subgroup and random effects meta-regression analyses will be used to further investigate the potential sources of heterogeneity. Otherwise, study-specific estimates will be pooled using either a fixed-effects or a random-effects model depending on the value of the I 2 statistic. In case a meta-analysis cannot be conducted, a descriptive analysis will be performed. The heterogeneity between studies will be assessed with the Cochrane’s Q statistic, and the I 2 statistic will measure the percentage of variation across studies that is due to their heterogeneity rather than chance it will decide if a meta-analysis can be conducted. Further, they will independently perform a qualitative assessment of the risk of bias and overall quality of the selected studies, followed by a quantitative assessment using funnel plots and Egger’s tests. Two investigators will select studies and use a pre-pilot tested form to extract data. Electronic sources including MEDLINE(PubMed), Embase, Cochrane Library, and Web of Science will be searched for potentially eligible studies, restricted to only studies published in English. The systematic review will include all observational studies published until Maand reporting on the prevalence of silent MI in diabetic patients.
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